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To evaluate the hypocalcemic effect of polyethylene gtycol-conjugated salmon calcitonins (PEG-sCT) in rats, mono-PEGylated sCTs (mono-PEG-sCTs) and unmodified sCT were administered via the intranasal route and serum calcium levels were measured by colorimetric assay using o-cresolphthalein. Mono-PEG-sCTs were prepared with different sizes of succinimidyl succinate monomethoxy PEG molecules (PEG2K,...
Vitamin D insufficiency contributes to bone loss and fracture risk. Low 25-hydroxyvitamin D (25OHD) levels are common in elderly people and in housebound and hospitalized patients. This study was conducted to assess wintertime 25OHD levels in relation to self-reported vitamin D supplement use in an outpatient thyroid clinic population. We assessed the medical history, vitamin D intake from milk and...
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