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Abstract
Evolution depends upon genetic variations that influence physiology. As defined in a genetic screen, phenotypic performance may be enhanced or degraded by such mutations. We set out to detect mutations that influence motor function, including motor learning. Thus, we tested the motor effects of 36,444 non‐synonymous coding/splicing mutations induced in the germline of C57BL/6J mice with...
Epilepsy constitutes the most common paroxysmal manifestation of glucose transporter type 1 deficiency (G1D) and is generally considered medication‐refractory. It can also prove therapeutic diet‐resistant. We examined acetazolamide effects in G1D motivated by several longstanding and recent observations: First, the electrographic spike‐waves characteristic of absence seizures often resemble those...
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