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Tumour-associated macrophages (TAMs) polarized to the protumoural M2 phenotype promote tumour proliferation and are considered to be a therapeutic target in patients with malignant tumours. In this study, we tried to identify natural compounds that inhibit TAM polarization into the M2 phenotype. We found that an extract of soybeans suppressed M2 polarization, and that soyasapogenols, major compounds...
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