Search results for: Rui Shen
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Characterization of the Dominant Autoreactive T-cell Epitope in Spontaneous Autoimmune Haemolytic Anaemia of the NZB Mouse
Journal of Autoimmunity > 2002 > 18 > 2 > 149-157
NZB mice spontaneously develop autoimmune haemolytic anaemia (AIHA) due to a T helper-dependent autoantibody response against the erythrocyte anion channel protein, Band 3. Here, we characterize the recognition of the Band 3 sequence 861–874, which carries the dominant, I-Ed-restricted T cell epitope. The ability of N and C-terminal truncated versions of peptide 861–874 to elicit NZB splenic T-cell...
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