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Spasmolytic polypeptide (SP/TFF2)-expressing metaplasia (SPEM) is induced by oxyntic atrophy and is known as a precancerous or paracancerous lesion. We seek to determine whether the gastrin receptor or H2 histamine receptor influence the development of SPEM. DMP-777 was administered to gastrin receptor and/or H2 receptor-deficient mice and wild-type mice. Gastric mucosal lineage changes were analyzed...
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