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A point mutation of G to C at codon 693 of the amyloid-beta (Aβ) precursor protein gene results in Glu to Gln substitution at position 22 of the Aβ (AβQ22) associated with hereditary cerebrovascular amyloidosis with hemorrhage Dutch type. Factors that regulate AβQ22 levels in the central nervous system (CNS) are largely unknown. By using ventriculo-cisternal perfusion technique in guinea pigs, we...
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