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Previously, we have demonstrated that human tissue kallikrein 1 (hKLK1) improves age‐related erectile dysfunction (ED). Autophagy has been implicated in age‐related diseases, including ED. However, the molecular mechanisms underlying hKLK1‐mediated amelioration of age‐related ED via regulation of autophagy remains unknown. To explore the potential mechanism, male wild‐type Sprague‐Dawley rats (WTR)...
Adipose‐derived stem cells (ADSCs) have recently been considered as a promising therapy for erectile dysfunction (ED). However, the mechanism of ADSC‐based therapy is unclear. Insulin‐like growth factor‐1 (IGF‐1), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) secreted by ADSCs were assessed in vitro. Sixteen 24‐month‐old male Sprague–Dawley rats were used for...
The aim of this study was to investigate the underlying mechanism of androgen deficiency inducing corporal fibrosis, thereby causing erectile dysfunction (ED). Forty 12‐week‐old healthy male rats were divided randomly into four groups: normal control group (Control); castration group (Castration); the other 20 rats were castrated followed by testosterone (T) (orally) each day: castration + 10mg/kg...
Men with hyperlipidemia are more likely to have erectile dysfunction (ED) than those without hyperlipidemia, but the mechanisms are not fully understood. The aim of this study was to investigate the underlying mechanism of ED caused by hyperlipidemia. Fourteen 8‐week‐old Sprague–Dawley rats were randomly divided into two groups: a control group and a hyperlipidemia group (fed chow containing 4% cholesterol...
Diabetic erectile dysfunction (ED) is a common complication in diabetes mellitus, and the efficacy of first‐line therapies is not satisfactory. Recent studies revealed that corporal apoptosis was responsible for the nonresponsiveness of severe ED to phosphodiesterase type 5 inhibitors. Mitofusin 2 (Mfn2) is a versatile protein, regulating mitochondrial morphology and playing an important role in apoptosis...
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