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A 128 × 128 ATP (Adenosine Triphosphate) image sensors using charge-coupled type ion image sensor with mixed layer technique of polyion complex were successfully fabricated to obtain 2D real time ATP image, and was carried out in a non-label manner. We obtained the diffusion image of ATP with the mixed layer method at the concentration as low as 100 µM. The sensitivity of the sensor was calculated...
To investigate the secretory properties in the neuronal networks, we developed the ion image sensor-based acetylcholine (ACh) imaging system utilizing with the ACh esterase-tagged magnet bead complexes. The magnetic particles were successfully placed only at the well of each sensing area of an ion image sensor (128 × 128 pixels type, 23 μπι pixel pitch). The pH value decreased immediately after the...
In order to develop the novel neuro-imaging technique, we constructed a high resolution type potassium ion (K+) image sensor (PIS). A K+-sensitive membrane was layered on the ion image sensor of 128 × 128 pixels array. By using the fabricated PIS, the extracellular concentration of the K+ ([K+]0) was detectable in the ranges between 10−3 and 10−1 M, which was consistent to the physiological ranges,...
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