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A needle type pH image sensor with 32×128 pixels for in-vivo application was developed. The pixel pitch of the sensor is 23 μm and the time resolution is about 20msec (50flame/sec). To insert in the brain of a mouse, the geometry was modified to needle structure with 1.76×11.46 mm and 100 μm thickness. The needle type pH image sensor was covered by parylene C with a thickness of 4 μm without pH sensing...
Non Labeled Image Sensing technology is strategic research area in bio-medical field. By combining imaging sensors with chemical sensors has developed novel ion image sensor that can visualize specific ions from cells in real time. Ions are crucial for sustaining the activities of living things, and understanding their behavior is critical for developing innovative drugs and devices based on chemical...
We propose a pixel construction for a pH image sensor with a new measurement method that spills charge to a potential wall under sensing area. The sensor pixel with 3 transistors has advantages for fabricating the sensor array with high spatial resolution compared with a conventional ISFET type sensor array using 4 transistors. The pixel size of the fabrication using the 3 transistor structure is...
This paper describes a hybrid device of a fluidic channel and electrodes for detection of membrane potential changes of Xenopus laevis oocytes (Xenopus oocytes). The fluidic device is composed poly(methyl methacrylate) and a silicon substrate that has needle-shaped structures for electrodes of two-electrode voltage clamping method that can measure ion flows across plasma membrane using a feedback...
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