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The ability to enrich rare cells, for example, circulating tumour cells, circulating foetal cells and stem cells, has been an important issue in medical diagnostics and characterisation. The main purpose of this investigation was to develop a handheld microdevice capable of the effective preconcentration of rare cells. Circular microelectrodes were designed to generate the stepping electric field...
We study the differential equations describing the chronic myeloid leukaemia. We propose a novel drug scheduling method to enhance the T-cell mediated immune response. The control strategy relies on the understanding of the immune boosting mechanism. The feasibility of the strategy is illustrated via simulations.
This paper describes a miniaturized oxygen sensor array integrated with heaters and temperature sensors and a LabVIEW-based measurement system which exactly can measure a cellular respiration level in a solution containing cells simultaneously. The designed oxygen sensor consists of Clark-type sensors, heaters, and temperature sensors of 2 times 3 array type on the substrate. 18 mum PDMS was used...
For a HIV dynamic model with immune system which strongly depends on the HIV target cells, we apply a recently proposed drug scheduling scheme: gradual reduction of drug dose. The feasibility of this scheme is analysed rigorously. By means of this method, the HIV patient is steered to an equilibrium condition known as long-term nonprogressor, which corresponds to an infected status not developing...
Membrane proteins organize themselves in a linear fashion where adjacent cells are attached together along the basal-lateral region. Their intensity distributions are often heterogeneous and may lack specificity. Grouping of these linear structures can aid in segmentation and quantitative representation of protein localization. However, quantitative analysis of these signals is often hindered by noise,...
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