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Optical molecular imaging can characterize and monitor multi molecular events in vivo, which providing a practical tool for early tumor diagnosis and drug development. To establish a research platform for optical molecular imaging, we develop the fluorescent protein-based genetically encoded optical probes, lipoprotein-based multi-functional nanocarrier, and optical molecular imaging systems.
A noninvasive, whole-body, real-time fluorescence optical imaging of stable high-level green fluorescent protein (GFP)—expressing human adenoid cystic carcinoma (ACC-M-GFP) was demonstrated for in vivo visualization of metastatic behavior in nude mice. Five-week-old female nude mice were injected with ACC-M-GFP in the primary organ: submandibular gland. Metastases were only visualized by GFP expression...
The purpose of this study was to define and characterize carbocyanine labeled low-density lipoprotein (LDL) to be used in the optical imaging of LDL receptor (LDLr)-overexpressing tumor models. 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) was used to label LDL (DiI-LDL). Scatchard plots were generated to determine the maximum binding capacity B max and dissociation...
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