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The effect of increasing amounts of amyloid β-protein (Aβ) on the number of neurons in the striatum was investigated in APPswe/PS1ΔE9 transgenic mice. This mouse model of Alzheimer's disease-like amyloidosis displays an increased expression of Aβ in the brain with age. On the basis of reports of disruptions in the anatomy of this part of the brain and the neurotoxic effects of amyloid, it was hypothesized...
Recent studies have demonstrated that amyloid-β 1–42 (Aβ 1–42 ) binds to the nicotinergic α 7 acetylcholine receptor (α 7 nAChR) and that the application of Aβ 1–42 to cells inhibits the function of the α 7 nAChR. The in vivo consequences of the pharmacological activation of the α 7 nAChR have not been examined. The aim of this study has been...
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