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We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective role of exogenous melatonin on these changes in young rats treated with cumene hydroperoxide (CH), a compound that promotes lipid peroxidation and inhibits protein synthesis. The study was performed using male Wistar rats of 3 (control), 12, and 24 months and 3‐month‐old rats...
Abstract: As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of the decline of translation in old animals are the modifications of elongation factor‐2 (eEF‐2). eEF‐2 occupies an essential role in protein synthesis where it catalyzes the ribosomal translocation reaction. eEF‐2 is particularly sensitive to increased oxidative stress...
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