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Abstract FK409 is the first spontaneous nitric oxide (NO) donor known to increase plasma cyclic guanosine 3,5monophosphate levels. In this study, we evaluated the effect of FK409 on pulmonary ischemia-reperfusion injury in an in situ warm ischemia canine model. Fourteen dogs were divided into two groups, and the FK409-treated group was given 5 g/kg per min FK409. Warm ischemia was induced for 3 h...
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