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5S rRNA plays an important part in ribosome biology and is over-expression in multiple cancers. In this study, we found that 5S rRNA is a direct target of miR-150 and miR-383 in esophageal squamous cell carcinoma (ESCC). Overexpression of miR-150 and miR-383 inhibited ESCC cell proliferation in vitro and in vivo. Moreover, 5S rRNA silencing by miR-150 and miR-383 might intensify rpL11–c-Myc interaction,...
5S rRNA plays an important part in ribosome biology and is over‐expression in multiple cancers. In this study, we found that 5S rRNA is a direct target of miR‐150 and miR‐383 in esophageal squamous cell carcinoma (ESCC). Overexpression of miR‐150 and miR‐383 inhibited ESCC cell proliferation in vitro and in vivo. Moreover, 5S rRNA silencing by miR‐150 and miR‐383 might intensify rpL11–c‐Myc interaction,...
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