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Chronic pain is a significant public health problem with a lack of safe and effective analgesics. The imidazoline I2 receptor (I2R) is a promising analgesic target, but the neuroanatomical structures involved in mediating I2R‐associated behaviors are unknown. I2Rs are enriched in the arcuate nucleus, dorsal raphe (DR), interpeduncular nucleus, lateral mammillary body, medial habenula, nucleus accumbens...
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