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Though gold nanoparticles have been considered bio-inert, recent studies have questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of gold and iron oxide as a nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, we demonstrate acid and macrophage lysosomal degradation of nanorose via loss of the near-infrared...
Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are used as contrast agents for photoacoustic imaging due to their strong absorptive property. However, there are concerns about using these nanoparticles in-vivo because they are not biodegradable and cannot...
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