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Calcium-calmodulin (CaM) binding to the epidermal growth factor receptor (EGFR) has been shown to both inhibit and stimulate receptor activity. CaM binds to the intracellular juxtamembrane (JM) domain (Met 645 –Phe 688 ) of EGFR. Protein kinase C (PKC) mediated phosphorylation of Thr 654 occurs within this domain. CaM binding to the JM domain inhibits PKC phosphorylation and...
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