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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used for the detection and assessment of coronary artery disease. While myocardial ischemia may be detected visually from the MR images by trained cardiologists or radiologists, it is likely that semi-quantitative or quantitative analysis of the dynamic images can improve the accuracy of diagnoses. Such analyses have yet to be standardized...
Magnetic resonance imaging (MRI) based approaches are supporting rapid advances in all phases of the management of atrial fibrillation (AF) patients, especially with the use of contrast agents and novel MRI acquisition techniques. In this report, we summarize briefly some recent advances in our use of MRI for AF management with special focus on the impact of these findings on the modeling and simulation...
The advent of partially parallel k-space data acquisition and reconstruction techniques has resulted in a drastic reduction in acquisition time. In this work, we have shown that the use of a new hybrid technique for reconstruction of partial k-space data can reduce acquisition time without loss of spatiotemporal resolution. The technique is termed hybrid k-t GRAPPA since it is a combination of k-t...
In magnetic resonance imaging (MRI), surface coils have the advantage of higher signal to noise ratio (SNR) but suffer from image inhomogeneity due to the non-uniform sensitivity profile. To remove bright spots caused by non-uniform sensitivity profiles, a gradient weighted smoothing method is discussed in this work. A partial differential equations (PDE) based model is applied for this locally adaptive...
In magnetic resonance imaging, multi-channel phased array coils enjoy a high signal to noise ratio (SNR) and better parallel imaging performance. But with the increase in number of channels, the reconstruction time and requirement for computer memory become inevitable problems. In this work, principle component analysis is applied to reduce the size of data and protect the performance of parallel...
Coronary artery disease (CAD), a leading cause of death in the US and worldwide, can be effectively diagnosed and assessed using non-invasive myocardial perfusion MRI. Tracer kinetic models play a crucial role in the analysis and quantification of perfusion. In this work, we evaluate the performance of 3 different kinetic models used to analyze perfusion: (a) a modified 2-compartment model (b) the...
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