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BACKGROUND:Adenovirus (Ad)‐mediated E2F‐1 gene transfer induces apoptosis in cancer cells in vitro and in vivo, but clinical application of E2F‐1 in cancer gene therapy remains controversial because of the oncogenic potential of E2F‐1. This barrier can be circumvented by using the truncated form of the E2F‐1 gene (E2Ftr) (amino acids 1 through 375), which lacks the E2F‐1 transactivation domain and...
Adenoviral vectors are highly efficient at transferring genes into cells and are broadly used in cancer gene therapy. However, many therapeutic genes are toxic to vector host cells and thus inhibit vector production. The truncated form of E2F-1 (E2Ftr), which lacks the transactivation domain, can significantly induce cancer cell apoptosis, but is also toxic to HEK-293 cells and inhibits adenovirus...
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