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B cells infiltrate tumors, but little is known about how they affect tumor growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16-1 or miRNA16-1) regulate cell proliferation, apoptosis, and drug resistance. We investigated their involvement in B-cell–mediated immune suppression by colorectal tumors.Mice with disruptions of the gene cluster that encodes MIR15A and MIR16–1...
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