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Background
The odds of erectile dysfunction are three times more prevalent in diabetes. Severe peripheral vascular and neural damage in diabetic patients responds poorly to phosphodiesterase‐5 (PDE5) inhibitors. However, bone morphogenetic protein 2 is known to be involved in angiogenesis.
Objectives
To assess the efficacy of bone morphogenetic protein 2 in stimulating angiogenesis and augmenting...
Background
The incidence of diabetic erectile dysfunction (ED) is rapidly increasing, and due to the severe angiopathy caused by diabetes, current drugs are ineffective at treating ED. Insulin‐like growth factor‐binding protein 5 (IGFBP5) promotes cell death and induces apoptosis in various cell types.
Objectives
To evaluate the effectiveness of IGFBP5 knockdown in improving erectile function in...
Background
Radical prostatectomy induces some degree of cavernous nerve injury (CNI) and causes denervation‐induced pathologic changes in cavernous vasculature, regardless of the advances in surgical techniques and robotic procedures. The precursor for nerve growth factor (proNGF) is known to be involved in neuronal cell apoptosis and microvascular dysfunction through its receptor p75NTR.
Objectives...
Background
Severe peripheral angiopathy in patients with diabetes is a major contributing factor for low response rate to phosphodiesterase‐5 inhibitors.
Objectives
To examine whether and how Dickkopf3 (DKK3), a secreted modulator of the Wnt pathway that known to be involved in endothelial cell repair and vascular progenitor cell migration, restores erectile function in diabetic mice.
Methods...
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