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BackgroundPrevious data showed that, in rats, anti‐migraine drugs (triptans, olcegepant) significantly reduced mechanical allodynia induced by infraorbital nerve (ION) ligation but not that evoked by sciatic nerve (SN) ligation. Whether this also occurs with MK‐8825, a novel anti‐migraine drug also acting through CGRP receptor blockade (but chemically unrelated to olcegepant) was tested in the present...
BackgroundConvergent data showed that neuropathic pain has specific characteristics at cephalic versus extra‐cephalic level, where single‐targeted drugs differentially alleviate pain. Because the novel analgesic drug, tapentadol, is acting at two targets, μ‐opioid receptors (as agonist) and noradrenaline reuptake (as inhibitor), we tested its effects on neuropathic pain at both cephalic and extra‐cephalic...
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