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It is largely described in literature that cancer cells produce a high level of reactive oxygen species (ROS) which induce the overexpression of scavenging systems such as the thioredoxin system. The key protein of this thiol redox regulating system is the selenoenzyme thioredoxin reductase (TrxR) which exist in cells in two isoforms (cytosolic and mitochondrial). Some metal complexes are able to...
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