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We and others have previously demonstrated that nociception in the mouse is heritable. A genetic correlation analysis of 12 common measures of nociception among a common set of inbred strains revealed three major clusters (or 'types') of nociception in this species. In the present study, we re-evaluated the major types of nociception and their interrelatedness using ten additional assays of nociception...
Individual differences in sensitivity to pain and analgesia are well appreciated, and increasing evidence has pointed towards a role of inherited genetic factors in explaining some proportion of such variability. It has long been known by practitioners of acupuncture, an ancient modality of analgesia, that some patients are 'responders' and others 'non-responders.' The present research was aimed at...
This work was designed to elucidate the possible involvement of endogenous endomorphin-l (EM1) in analgesia induced by electroacupuncture of low or high frequencies. Taking radiant heat tail flick latency (TFL) as an indication of nociception, rats were subjected to intrathecal (i.t.) injection of 10 μl antiserum against EM1 (EM1-AS) or normal rabbit serum (NRS, as control) and then followed by 2...
The menstrual history of 162 cases of female lung adenocarcinoma and 19 cases of squamous cell carcinoma was compared with 187 age-matched female controls, and analyzed for statistical significant differences that may exist between the two groups using the Epi-infor program, the Chi-square test, and the Bartlett test for homogeneity of variance. Parameters related to menstrual history included: age...
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