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The extended use of doxorubicin (DOX) could be limited due to the emergence of drug resistance and cardiotoxicity associated with its treatment. Conjugates of DOX with transferrin (DOX–TRF) can effectively alleviate these side effects, thereby leading to a better treatment. The effectiveness of DOX–TRF could result from the enhancement of transferrin receptor (TfR)-mediated transportation. However,...
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