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Synthesis and cytotoxicity of 11 4-methylene pyrido[4,3-d]pyrimidines 5a–k were described. Cytotoxicity assay results showed that some compounds had much stronger antitumor activity than Fluorouracil against KB cell lines. The most active compound 5i exhibited high potency against KB, CNE2, MGC-803 cell lines with IC 50 values of 0.48, 0.15, 0.59μM, respectively. The preliminary structure–activity...
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