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A new technique is described for the formation of ligand-targeted liposomes that can be used with whole antibodies, antibody fragments, peptides or other ligands. The ligands are coupled to polyethylene glycol micelles and then transferred in a simple incubation step from the micelles into the outer monolayer of pre-formed, drug-loaded liposomes, This versatile method allows a combinatorial approach...
Ligand-targeted liposomes have the potential to increase the therapeutic efficacy of antineoplastic agents. Recently, a combinatorial approach to the preparation of ligand-targeted liposomes has been developed, termed the post-insertion technique, which will facilitate the production of targeted liposomes. In this paper, Stealth immunoliposomes (SIL) coupled to anti-CD19 made by either a conventional...
In the last few years a number of advances took place in development of methodologies for preparation of polyethylene glycol (PEG)-grafted immunoliposomes. Several new end-group functionalized PEG lipids were introduced for this purpose. These include pyridyldithiopropionate-PEG- and hydrazide-PEG-PE derivatives, which incorporate well into liposomes and are used for covalent attachment of antibodies...
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