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Background & Aims: Sex steroids influence IBD symptoms. Macrophage migration inhibitory factor (MIF), a target of sex steroids in other inflammatory models, promotes interleukin (IL)-1β and tumor necrosis factor (TNF)-α release in colitis. We investigated whether estradiol and progesterone influence MIF, IL-1β, and TNF-α production in experimental colitis. Methods: Colonic MIF, IL-1β, and TNF-α...
Background & Aims: The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal tumorigenesis. Methods: MIF messenger RNA, protein, and tautomerase activity...
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