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Coptisine, one of the main components isolated from Coptidis rhizoma, has been reported to have many beneficial pharmacological effects including anti‐inflammatory, anti‐hypercholesterolemia, neuroprotective and cardioprotective properties. However, to date the information related to the in vivo pharmacokinetics (PK) of coptisine is very limited. The purposes of our study are to establish a fast and...
A sensitive and reliable LC‐ESI‐MS method for the determination of salvianolic acid C in rat plasma has been developed and validated. Plasma samples were prepared by liquid–liquid extraction with ethyl acetate and separated on a Zorbax SB‐C18 column (3.5 µm, 2.1 × 100 mm) at a flow rate of 0.3 mL/min using acetonitrile–water as mobile phase. The detection was carried out by a single quadrupole mass...
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