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In oculo transplantation provides a powerful tool to study development and gene expression of isolated brain regions. In this study we grafted striatal and mesencephalic brain tissue to the anterior eye chamber and allowed it to survive for 2 and 6 weeks. Striatal or mesencephalic pieces were either grafted alone (single grafts) or together in close connection (co-grafts). As a control normal adult...
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, expresses potential effects on survival and outgrowth from dopaminergic neurons in ventral mesencephalon. In this study we have examined the expression of BDNF mRNA and its high affinity trkB receptor mRNA in the nigrostriatal system after grafting to the anterior chamber of the eye. The BDNF mRNA expression has been...
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