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To determine Korean mistletoe lectin (KML-C) functions as a mucosal adjuvant, we monitored its ability to modulate the immune response after intranasal immunization with hemagglutinin (HA) as an antigen. Mucosal and systemic immune responses with KML-C were compared to responses with cholera toxin B subunit (CTB) as an adjuvant. Intranasal co-administration of HA and KML-C in mice resulted in increased...
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