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Background
Atoh1 is recognized to be essential for cochlear hair cell (HC) development. However, Atoh1 temporal and spatial expression patterns remain widely debated. Here, we aimed to obtain evidence to resolve the controversies regarding Atoh1 expression by generating a new knockin mouse strain: Atoh13*HA‐P2A‐Cre.
Results
Fate‐mapping analysis of Atoh13*HA‐P2A‐Cre/+; Rosa26‐CAG‐LSL‐tdTomato (Ai9)/+...
Background
Conditional loss‐of‐function studies are widely conducted using the Cre/Loxp system because this helps circumvent embryonic or neonatal lethality problems. However, Cre strains specific to the inner ear are lacking, and thus lethality frequently occurs even in conditional knockout studies.
Results
Here, we report a Rorb‐IRES‐Cre knockin mouse strain in which the Cre recapitulates the...
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