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The highly polymorphic fourth component of human complement (C4) is usually encoded by two genes, C4A and C4B, adjacent to the 21-hydroxylase (21-OH) genes, 21-OHA and 21-OHB, and is also remarkable in the high frequency of the 'null' alleles, C4A*Q0 and C4B*Q0. The molecular basis for the C4A*Q0 allele was studied in 26 families through restriction fragment length polymorphism (RFLP) analysis with...
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