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Both calcium and 1,25(OH) 2 D promote the differentiation of keratinocytes in vitro. The autocrine or paracrine production of 1,25(OH) 2 D by keratinocytes combined with the critical role of the epidermal calcium gradient in regulating keratinocyte differentiation in vivo suggest the physiologic importance of this interaction. The interactions occur at a number of levels. Calcium and...
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