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Background
Nelfinavir (NFV), an HIV‐1 protease inhibitor, has been shown to sensitize cancer cells to chemoradiation (CRT). The objectives of this phase 1 trial were to evaluate safety and identify the recommended phase 2 dose of NFV added to concurrent CRT for locally advanced cervical cancer.
Methods
Two dose levels of NFV were evaluated: 875 mg orally twice daily (dose level 1 [DL1]) and 1250...
Substantial progress has been made in understanding ovarian cancer at the molecular and cellular level. Significant improvement in 5‐year survival has been achieved through cytoreductive surgery, combination platinum‐based chemotherapy, and more effective treatment of recurrent cancer, and there are now more than 280,000 ovarian cancer survivors in the United States. Despite these advances, long‐term...
BACKGROUND
Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The University of Texas MD Anderson Cancer Center in Houston regarding actionability and...
BACKGROUND:The current study was conducted to determine the frequency and association between recurrence‐free survival (RFS) and MET and catalytic subunit of phosphoinositide‐3‐kinase (PIK3CA) copy number elevations in patients with early stage breast cancer.
METHODS:Tumor DNA was extracted from 971 formalin‐fixed, paraffin‐embedded early breast cancers for molecular inversion probes arrays. Data...
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