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A new isocratic stability indicating HPLC method for determination of tizanidine in drug substance and formulated products is described. Chromatographic separation of tizanidine from the related substances and degraded products was achieved with a Hypersil CN column (150mmx5.0mm, 5μm) using a mobile phase comprising a mixture of an ion-pairing solution of heptanesulphonic acid sodium salt (HAS), methanol...
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