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MyoD-mediated activation of skeletal muscle genes, which is dependent upon the consensus E-box sequence, involves, at least in one group of muscle genes, another transcription factor, the myocyte enhancer factor-2 (MEF-2). Since the cardiac myosin light chain-2 (MLC-2) gene promoter lacks the functional E-box but contains the activator MEF-2 site, we tested the effect of ectopic expression of MyoD...
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