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Aggregation of antibody light chain proteins is associated with the progressive disease light chain amyloidosis. Patient‐derived amyloid fibrils are formed from light chain variable domain residues in non‐native conformations, highlighting a requirement that light chains unfold from their native structures in order to aggregate. However, mechanistic studies of amyloid formation have primarily focused...
Background
Tracheobronchomalacia (TBM) and airway stenosis are recognized etiologies of airway obstruction among children. Their management is often challenging, requiring multiple interventions and prolonged respiratory support with associated long‐term morbidity. Metallic or silicone stents have been used with mixed success and high complication rates. More recently biodegradable Ella stents (BES)...