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A bicuculline-resistant and TPMPA-sensitive GABAergic component was identified in hippocampal neurons in culture and in acute isolated brain slices. In both preparations, total GABAergic activity showed two inactivation kinetics: fast and slow. RT-PCR, in situ hybridization (ISH) and immunohistochemistry detected expression of GABAρ subunits. Immunogold and electron microscopy indicated that the receptors...
Rationale Accumulating evidence for the presence of GABAA ρ receptors within the amygdala which differ from other members of the GABAA receptor family in both subunit composition and functional properties has been recently obtained. Objectives This work was conducted to study whether GABAA ρ receptors may have a putative role in the amygdaloid modulation of fear and anxiety. Results It was found...
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