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Forty years ago, we started our quest for ‘The Holy Grail’ of understanding ventricular rate control and rhythm in atrial fibrillation (AF). We therefore studied the morphology and function of a wide range of mammalian hearts. From mouse to whale, we found that all hearts show similar structural and functional characteristics. This suggests that the mammalian heart remained well conserved during evolution...
The purpose of this study was to investigate scaling of the duration of late diastolic left ventricular (LV) filling in relation to AV conduction time (delay) (PR interval on the ECG) in mammals. From mouse to whale, AV delay increases 10-fold, whereas body mass increases one million-fold. The apparent “mismatch” results from scaling of AV delay versus body and heart mass. We measured (1) mitral...
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