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Objective
This study aimed to evaluate the associations of age at first birth and parity with weight, waist circumference (WC), and body fat across midlife.
Methods
A secondary data analysis was conducted with 735 participants from Project Viva who reported their age at first birth and lifetime parity at a midlife study visit. Weight, WC, and body fat were measured up to four times after the participants'...
Objective
The aim of this study was to examine COVID‐19 pandemic‐related changes in obesity and BMI among patients aged 5 to <20 years with selected chronic conditions.
Methods
A longitudinal study in 293,341 patients aged 5 to <20 years who were prescribed one of five medication classes (for depression, psychosis, hypertension, diabetes, or epilepsy) and who had BMI measures from January...
Objective
This study examined the associations of central adiposity gain from midchildhood to early adolescence with cardiometabolic health markers in early adolescence.
Methods
A total of 620 participants were studied in Project Viva. In midchildhood (mean age = 7.8 years) and early adolescence (12.9 years), waist circumference and dual‐energy x‐ray absorptiometry‐measured visceral adipose tissue,...
Objective
The purpose of this study was to test the extent to which pregnancy per‐ and polyfluoroalkyl substance (PFAS) concentrations were associated with gestational weight gain and postpartum weight changes.
Methods
This study was composed of 1,614 women recruited between 1999 and 2002 via the Project Viva cohort with pregnancy plasma concentrations of six PFAS, including perfluorooctanesulfonic...
Objective
The purpose of this article is to characterize metabolomic profiles of four overweight/obesity (OWOB) and metabolic risk (MetRisk) phenotypes among 524 adolescents aged approximately 13 years.
Methods
A four‐level phenotype variable (non‐OWOB and low MetRisk, non‐OWOB and high MetRisk, OWOB and low MetRisk, and OWOB and high MetRisk) was created using BMI percentile to define OWOB, and...
Objective
The aim of this study was to investigate the relationship of BMI with subsequent statural growth among children born in the era of the obesity epidemic.
Methods
Among 18,271 children from Belarus (n = 16,781, born 1996 to 1997) and the United States (n = 1,490, born 1999 to 2002), multivariable linear and ordinal logistic regression was used to analyze associations of BMI z score from...
Objective
Prepregnancy weight may not always be known to women. A model was developed to estimate prepregnancy weight from measured pregnancy weight.
Methods
The model was developed and validated using participants from two studies (Project Viva, n = 301, model development; and Fit for Delivery [FFD], n = 401, model validation). Data from the third study (Programming Research in Obesity, Growth,...
Objective
This study aimed to examine the associations of two obesity‐related metabolite patterns with changes in metabolic biomarkers during early adolescence.
Methods
Multivariable linear regression was used to examine associations of branched chain amino acid (BCAA) and androgen hormone patterns with changes in glycemia (fasting glucose, insulin, homeostatic model assessment of insulin resistance),...
ObjectiveIt is unclear how specific periods of gestational weight gain (GWG) during pregnancy relate to childhood adiposity. The goal of this study was to assess the differential impact of GWG timing on childhood body composition.
MethodsIn 979 mother–child pairs from the pre‐birth Project Viva cohort, trimester‐specific GWG was calculated using clinically recorded weights. Outcomes included body...
ObjectiveMaternal pre‐pregnancy obesity is associated with offspring obesity. Underlying mechanisms may involve a maternal obesity‐mediated proinflammatory state during pregnancy. Maternal C‐reactive protein (CRP) level during pregnancy is a biomarker of low‐grade systemic inflammation.
MethodsAmong 1,116 mother‐child pairs, this study examined associations of maternal second‐trimester CRP plasma...
ObjectiveTo assess the extent to which an obesity prevention intervention that embeds obesity‐related messages within a parenting program, compared with controls who received weekly mailings, resulted in a smaller increase in children's BMI (primary outcome) and improvements in weight‐related behaviors from baseline to 9‐month follow‐up.
MethodsFifty‐six families were randomly assigned to the intervention...
ObjectiveTo examine associations of chronic insufficient sleep with diet and whether diet explains the sleep‐adiposity relationship.
MethodsIn Project Viva, 1,046 parents reported children's sleep duration at 6 m and annually until midchildhood (7 y). The main exposure was a sleep curtailment score (6 m‐7 y) ranging from 0 (maximal curtailment) to 13 (adequate sleep). In mid‐childhood, parents reported...
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