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The majority of eukaryotic mRNAs are translated in a cap-dependent manner, which requires recognition of the mRNA 5′ cap by eIF4E protein. Multiple eIF4E family members have been identified in most eukaryotic organisms. Drosophila melanogaster (Dm) has eight eIF4E related proteins; seven of them belong to Class I and one to Class II. Their biological roles with the exception of Dm eIF4E-1, Dm eIF4E-3...
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