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Pre‐clinical and clinical studies in cocaine addiction highlight alterations in the striatal dopaminergic reward system that subserve maintenance of cocaine use. Using an instrumental conditioning paradigm with monetary reinforcement, we studied striatal functional alterations in long‐term abstinent cocaine‐dependent patients and striatal functioning as a function of abstinence and treatment duration...
Long-term cocaine consumption is associated with brain structural and functional changes. While the animal literature on cocaine use and dependence has traditionally focused on the striatum, previous human studies using voxel-based morphometry have reported reduced volumes of gray matter in several brain areas, but not in the striatum. Brain magnetic resonance imaging was performed with 20 cocaine-dependent...
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