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Objective The study was to establish a population pharmacokinetic (PPK) model of piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to propose optimized dosage regimens in patients with nosocomial infections. Methods In total, 310 PIP and 280 TAZ concentration–time points were collected at steady state over multiple dosing intervals from 50 patients who received...
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