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Purpose
Plasma markers that enable diagnosis in the early stage of lung cancer is not discovered. A liquid chromatography multiple reaction monitoring‐mass spectrometry (LC‐MRM‐MS) assay for identifying potential early marker proteins for lung adenocarcinoma is developed.
Experimental Design
LC‐MRM‐MS assay is used for measuring the level of 35 candidate peptides in plasma from 102 lung adenocarcinoma...
—Using selected reaction monitoring (SRM) a targeted analysis of proteins that were previously reported to be associated with lung cancer (Novikova, S.E. et al., Biomeditsinskaya khimiya, 2017, vol. 63, pp. 181−210 [1]) was carried out. Measurements were performed using: 23 samples of plasma of patients with lung adenocarcinoma (LAC), 11 samples of plasma of patients with squamous cell lung carcinoma...
Tissue inhibitor metalloproteinase-1 (TIMP-1) is clinically associated with a poor prognosis for various cancers, but the roles of TIMP-1 in lung cancer metastasis are controversial. Our previous secretomic study revealed that TIMP-1 is highly abundant in high invasiveness cells of lung adenocarcinoma. In the current study, TIMP-1 abundances in primary lung adenocarcinoma tissues, as revealed by immunohistochemistry,...
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