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The complement system can provoke but also participate in the repair of liver injury. Here we investigated by microarray analysis the effect of chronic ethanol consumption on hepatic mRNA expression of complement components and acute-phase proteins in complement C3-deficient (C3 −/− ) and wild-type (C3 +/+ ) mice. Up-regulation by ethanol of factor B, C1qA-chain and clusterin but down-regulation...
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