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A novel quinoline derivative, TAS-103 (6-[[2-(dimethylamino)ethy]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride), was developed as an anticancer agent targeting topoisomerases (topo) I and II, with marked efficacy in solid tumors. TAS-103 inhibited topo I and II (IC 50 : 2 μM, 6.5 μM) at a concentration similar to or lower than those of previous agents, and had a strong...
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