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Naturally occurring interleukin‐2 (IL‐2) is a pleiotropic glycoprotein that regulates immune responses by controlling the differentiation and homeostasis of T cells. Non‐glycosylated IL‐2 has been used in clinical settings for three decades. However, the function of the O‐glycan of native IL‐2 remains elusive. Herein, to stress this issue, we report a highly efficient semi‐synthesis of homogeneous...
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