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Mittel gegen Superbugs? Zwei neue synthetische dikationische Peptoide (siehe Beispiel; rot O, blau N, grün Cl) zeigen vielversprechende antibakterielle Aktivität in vitro gegen etliche Gram‐positive Pathogene – einschließlich Vancomycin‐, Methicillin‐ und Linezolid‐resistenter Organismen – bei nur langsamer Resistenzentwicklung. Ihre Wirksamkeit bleibt darüber hinaus auch in vivo erhalten.
Superbugs stalled! Two newly designed synthetic dicationic peptoids (see one example; red O, blue N, green Cl) show promising in vitro bactericidal activity against a range of Gram‐positive pathogens, including organisms resistant to vancomycin, methicillin, and linezolid, with only slow development of resistance. Moreover their potency is maintained in vivo.
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